![]() There are no FDA approved CrAg assays for urinary samples. Additionally, the use of highly sensitive and specific serum and cerebrospinal fluid (CSF) lateral flow antigen assays to detect Cryptococcal capsular antigens from clinical samples have become important non-culture based diagnostic tools. Increasingly, the use of proteomic techniques such as MALDI-TOF MS and DNA sequencing of the internal transcribed spacer (ITS) region of the nuclear ribosomal DNA have replaced traditional phenotypic methods for identification from culture. neoformans is typically opaque to white and mucoid appearing on blood agar, while strains lacking capsules may appear dry. Though colony morphology is not a specific diagnostic feature, C. ![]() neoformans growing from clinical samples traditionally involves routine microbiology workup including specific staining techniques along with selective and differential media. One retrospective study in an 800-bed hospital over 12 years found an incidence of 0.56 patients per 100,000. Cryptococcuria is a rare clinical finding. Once inhaled, pulmonary infection can lead to hematogenous spread, most often to the central nervous system but occasionally to skin, bone, and rarely the prostate or bladder. The cryptococcal polysaccharide capsule is its main virulence factor, allowing it to evade host immunity and readily disseminate. Cryptococcus neoformans is a free living saprobic encapsulated yeast that is ubiquitous in the environment and typically causes infection in patients with immunocompromising conditions such as HIV, hematologic malignancy, or organ transplantation.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |